Verbascoside
Verbascoside is a phenylpropanoid found in a variety of species of Castilleja, Verbena, and Verbascum. Verbascoside displays anti-inflammatory, analgesic, antioxidative, and antithrombotic properties in a variety of cellular and animal models. In vitro, verbascoside inhibits arachidonic acid- and ADP-induced platelet aggregation as well as dipeptidyl peptidase 4 (DPP4) and prolyl oligopeptidase activity. In vivo, verbascoside decreases levels of Bax, Bcl-2, NF-κB, iNOS, and myeloperoxidase, showing anti-inflammatory benefit in a model of periodontitis. Additionally, this compound inhibits mechanical pain in two different animal models of hyperalgesia. Verbascoside may also be an inhibitor of PKC.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18978790
| Cas No. |
61276-17-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C29H36O15 |
| Formula Wt. |
624.59 |
| IUPAC Name |
[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl](E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| Synonym |
Acteoside |
| Appearance |
Off-white powder |
Campo G, Marchesini J, Bristot L, et al. The in vitro effects of verbascoside on human platelet aggregation. J Thromb Thrombolysis. 2012 Oct;34(3):318-25. PMID: 22723176.
Filho AG, Morel AF, Adolpho L, et al. Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity. Phytother Res. 2012 Oct;26(10):1472-5. PMID: 22275311.
Paola RD, Oteri G, Mazzon E, et al. Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis. J Pharm Pharmacol. 2011 May;63(5):707-17. PMID: 21492173.
Isacchi B, Iacopi R, Bergonzi MC, et al. Antihyperalgesic activity of verbascoside in two models of neuropathic pain. J Pharm Pharmacol. 2011 Apr;63(4):594-601. PMID: 21401613.
Kahraman C, Tatli II, Orhan IE, et al. Cholinesterase inhibitory and antioxidant properties of Verbascum mucronatum Lam. and its secondary metabolites. Z Naturforsch C. 2010 Nov-Dec;65(11-12):667-74. PMID: 21319708.
