Triclosan
Triclosan is a diarylether antimicrobial often found in commercial soap products. Triclosan exhibits antibacterial, antifungal, antiviral, and anti-inflammatory activities. Triclosan binds bacterial enoyl-acer carrier protein reductase (ENR), increasing its affinity for NAD+ and forming a complex that prevents fatty acid synthesis and bacterial cell membrane formation. Triclosan also inhibits LPS-induced pro-inflammatory responses in epithelial cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18978032
| Cas No. |
3380-34-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H7Cl3O2 |
| Formula Wt. |
289.54 |
| IUPAC Name |
5-chloro-2-(2,4-dichlorophenoxy)phenol |
| Appearance |
White Crystal Powder |
Wallet MA, Calderon Nl, Alonso TR, et al. Triclosan alters antimicrobial and inflammatory responses of epithelial cells. Oral Dis. 2013 Apr;19(3):296-302. PMID: 24079913.
Twanabasu BR, Smith CM, Stevens KJ, et al. Triclosan inhibits arbuscular mycorrhizal colonization in three wetland plants. Sci Total Environ. 2013 Mar 1;447:450-7. PMID: 23410867.
Russell AD. Whither triclosan? J Antimicrob Chemother. 2004 May;53(5):693-5. PMID: 15073159.
