Sulfadoxine
Sulfadoxine is a sulfonamide anti-parasitic that inhibits dihydropteroate synthase, preventing folate synthesis and increases blood oxygen levels. Sulfadoxine exhibits antimalarial activity and is typically given with pyrimethamine.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18974129
| Cas No. |
2447-57-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H14N4O4S |
| Formula Wt. |
310.33 |
| Chemical Name |
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)- benzenesulfonamide |
| IUPAC Name |
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide |
| Synonym |
Fanasil; Fanzil; Sulforthomidine |
| Melting Point |
190-194°C |
| Solubility |
Soluble in dilute mineral acids, solutions of alkali hydroxides and carbonates. Slightly soluble in water and methanol. |
| Appearance |
White Crystal Powder |
Combrinck JM, Mabotha TE, Ncokazi KK, et al. Insights into the role of heme in the mechanism of action of antimalarials. ACS Chem Biol. 2013 Jan 18;8(1):133-7. PMID: 23043646.
Abebe W. Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. Ethiop Med J. 2006 Apr;44(2):133-8. PMID: 17447375.
