Sulbactam
Sulbactam is a β-lactamase inhibitor that is administered clinically to improve the efficacy of carbapenem antibiotics. Sulbactam is often administered to improve antibacterial efficacy against Enterobacter and Staphylococcus.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18974038
| Cas No. |
68373-14-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C8H11NO5S |
| Formula Wt. |
233.25 |
| Chemical Name |
(2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| IUPAC Name |
(2S,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Synonym |
CP 45899 |
| Melting Point |
148-151°C |
| Solubility |
Soluble in water. |
| Appearance |
Light Orange Powder |
Li R, Liao JM, Gu CR, et al. Theoretical investigation on reaction of sulbactam with wild-type SHV-1 β-lactamase: acylation, tautomerization, and deacylation. J Phys Chem B. 2011 Sep 1;115(34):10298-310. PMID: 21797222.
Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. PMID: 20065329.
