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Somatostatin-28

Somatostatin is an endogenous neuropeptide hormone found in the brain and pancreas. Somatostatin binds several isoforms of the somatostatin receptor, exhibiting anxiolytic, antiepileptic/anticonvulsant, and anorexigenic activities. In vivo, somatostatin improves performance in the light/dark avoidance test. Somatostatin also suppresses seizures and prevents the generation of seizures, potentially through modulation of GABA signaling. Somatostatin induces cell death under hypoxic/ischemic conditions. In tumor cells, somatostatin displays pro-apoptotic properties, potentially involving the inhibition of PI3K/Akt signaling. Somatostatin also limits food intake and inhibits secretion of insulin and glucagon through alteration of Gβγ signaling and P/Q-type N-type, and L-type voltage-gated Ca2+ channel signaling.

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18973661/

Cas No.

75037-27-3

Purity

≥98%

Formula

C137H207N41O39S3

Formula Wt.

3148.6

Synonym

Prosomatostatin

Solubility

Soluble in water.

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Takahashi M, Takeda M, Matsumoto S. Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons. Brain Res Bull. 2014 Jan;100:76-83. PMID: 24321530.

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Schwetz TA, Ustione A, Piston DW. Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms. Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E211-21. PMID: 23211512.

Kailey B, van de Bunt M, Cheley S, et al. SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells. Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1107-16. PMID: 22932785.

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