Rolipram
Rolipram is known to be an antidepressant and anxiolytic-like agent that has been found to stimulate angiogenesis and attentuate neuronal apoptosis in ischemic rats.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18964309
| Cas No. |
61413-54-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H21NO3 |
| Formula Wt. |
275.35 |
| IUPAC Name |
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
| Synonym |
ZK62711 |
| Melting Point |
128-129°C |
| Solubility |
Soluble in DMSO (warm 25mg/ml), ethanol (25 mg/ml warm). |
| Appearance |
White to off-white powder |
Hu S, Cao Q, Xu P, et al. Rolipram stimulates angiogensis and attenuates neuronal apoptosis through the cAMP/cAMP-responsive element binding protein pathway following ischemic stroke in rats. Exp Ther Med. 2016 Mar; 11(3):1005-1010. PMID: 26998028.
Li YF, Huang Y, Amsdell S, et al. Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus. Neuropsychopharmacology. 2009 Oct; 34(11):2404-2419. PMID: 19516250.
