Rigin
Rigin is a tuftsin-like tetrapeptide with the sequence G-Q-P-R that is derived from IgG. Rigin exhibits immunomodulatory activity, stimulating phagocytosis, activating polymorphonuclear lymphocytes and macrophages, and protecting against stress-induced damage.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18959567
| Cas No. |
77727-17-4 |
|---|---|
| Purity |
≥95% |
| Formula |
C18H32N8O6 |
| Formula Wt. |
456.51 |
| IUPAC Name |
(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| Synonym |
G-Q-P-R; GQPR |
Dutta RC, Puri A, Anand N. Immunomodulatory potential of hydrophobic analogs of Rigin and their role in providing protection against Plasmodium berghei infection in mice. Int Immunopharmacol. 2001 May;1(5):843-55. PMID: 11379040.
Klusha VE, Mutsenietse RK, Svirskis ShV, et al. Neuroimmunoregulatory properties of short protein fragments in rats exposed to immobilization stress. Biull Eksp Biol Med. 1987 Aug;104(8):186-7. PMID: 2887222.
Veretennikova NI, Chipens GI, Nikiforovich GV, et al. Rigin, another phagocytosis-stimulating tetrapeptide isolated from human IgG. Confirmations of a hypothesis. Int J Pept Protein Res. 1981 Apr;17(4):430-5. PMID: 7309346.
