Ramipril
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor that exhibits anti-arrhythmic, antihypertensive, and cardioprotective activities. In animal models of myocardial infarction, ramipril decreases ventricular tachycardia and ventricular fibrillation. In other, similar animal models, ramipril increases antioxidative enzyme activity, improving left ventricular ejection fraction and inhibiting left ventricular remodeling. Ramipril is clinically used to treat high blood pressure, congestive heart failure (CHF), and diabetic neuropathy.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18957430
| Cas No. |
87333-19-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C23H32N2O5 |
| Formula Wt. |
416.51 |
| Chemical Name |
[2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3- phenylpropyl]amino]-1-oxopropyl]octahydrocyclo- penta[b]pyrrole-2-carboxylic acid |
| IUPAC Name |
(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid |
| Synonym |
Tritace; Ramace; Unipril; Vesdil |
| Melting Point |
109°C |
| Solubility |
Soluble in DMSO (10mg/mL).and Acetonitrile |
| Appearance |
White Crystal Powder |
Zhong Y, Cao P, Tong C, et al. Effect of ramipril on the electrophysiological characteristics of ventricular myocardium after myocardial infarction in rabbits. J Cardiovasc Med (Hagerstown). 2012 May;13(5):313-8. PMID: 22441218.
Chen CY, Lee BC, Hsu HC, et al. A proteomic study of the effects of ramipril on post-infarction left ventricular remodelling in the rabbit. Eur J Heart Fail. 2008 Aug;10(8):740-8. PMID: 18583185.
Dupuis F, Atkinson J, Limiñana P, et al. Comparative effects of the angiotensin II receptor blocker, telmisartan, and the angiotensin-converting enzyme inhibitor, ramipril, on cerebrovascular structure in spontaneously hypertensive rats. J Hypertens. 2005 May;23(5):1061-6. PMID: 15834293.
