Ramatroban
Ramatroban is a thromboxane A2 (TxA2) receptor inhibitor that exhibits anti-allergic and anti-inflammatory properties. Ramatroban also competitively inhibits chemoattractant receptor-homologous molecule on Th2 cells (CRTH2), a relatively new prostaglandin D2 (PGD2) receptor. Ramatroban decreases expression of inflammatory mediator IL-16 and also inhibits expression of adhesion molecules and prevents infiltration of immune cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18957415
| Cas No. |
116649-85-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C21H21FN2O4S |
| Formula Wt. |
416.47 |
| IUPAC Name |
3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid |
| Solubility |
Ethanol (30 mg/ml), DMSO (30 mg/ml), DMF (30 mg/ml) |
| Appearance |
White to off white powder |
Suzuki Y, Inoue T, Yamamoto A, et al. Prophylactic effects of the histamine H1 receptor antagonist epinastine and the dual thromboxane A2 receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells antagonist ramatroban on allergic rhinitis model in mice. Biol Pharm Bull. 2011;34(4):507-10. PMID: 21467637.
Akiyama K, Karaki M, Kobayshi R, et al. IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model. Int Arch Allergy Immunol. 2009;149(4):315-22. PMID: 19295235.
Sugimoto H, Shichijo M, Okano M, et al. CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. PMID: 16256979.
Shiraishi Y, Asano K, Nakajima T, et al. Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. J Pharmacol Exp Ther. 2005 Mar;312(3):954-60. PMID: 15528449.
Ishizuka T, Matsui T, Okamoto Y, et al. Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovasc Drug Rev. 2004 Summer;22(2):71-90. PMID: 15179446.
