Radicicol
Radicicol is an analog of benzoquinone ansamycin that inhibits HSP90, Src family kinases, and Raf. Radicicol exhibits neuroprotective, antibiotic, antifungal, anti-parasitic, and antimalarial activities. In Plasmodium, radicicol targets topoisomerase VI-B, inhibiting mitochondrial replication. Radicicol also increases survival and neurite outgrowth of neurons in chick embryos.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18957284
| Cas No. |
12772-57-5 |
|---|---|
| Purity |
≥96% |
| Formula |
C18H17ClO6 |
| Formula Wt. |
364.78 |
| Chemical Name |
8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihyroxy-14- methyl-6H-oxireno[e][2]benzoxacyclotetradecin- 6,12(7H)-dione |
| Synonym |
Monorden; Monorderne |
| Melting Point |
193.5°C |
| Solubility |
Soluble in DMSO, methanol or ethanol. |
| Appearance |
White Crystal Powder |
Chalapareddy S, Bhattacharyya MK, Mishra S, et al. Radicicol Confers Mid-Schizont Arrest by Inhibiting Mitochondrial Replication in Plasmodium falciparum. Antimicrob Agents Chemother. 2014 Aug;58(8):4341-4352. PMID: 24841259.
Gadelle D, Bocs C, Graille M, et al. Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol. Nucleic Acids Res. 2005 Apr 22;33(7):2310-7. PMID: 15849317.
Sano M, Yoshida M, Fukui S, et al. Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo. J Neurochem. 1999 Jun;72(6):2256-63. PMID: 10349833.
