RKI-1447
RKI-1447 is an inhibitor of ROCK1/2 that exhibits anticancer chemotherapeutic activity. RKI-1447 also displays anti-metastatic potential, suppressing phosphorylation of MLC-2, MYPT-1, inhibiting formation of actin stress fibers, and preventing migration, invasion, and growth of breast cancer cells and tumors.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18962445
| Cas No. |
1342278-01-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H14N4O2S |
| Formula Wt. |
326.37 |
| IUPAC Name |
1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea |
| Synonym |
RKI1447 |
| Appearance |
White to off white powder |
Patel RA, Forinash KD, Pireddu R, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. PMID: 22846914.
