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Pyrrolostatin

Pyrrolostatin is a pro-angiogenic free radical scavenger that improves angiogenesis in animal models. Pyrrolostatin is a lipid peroxidation inhibitor originally produced by species of Streptomyces.

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18955860

Cas No.

144314-68-1

Purity

≥98%

Formula

C15H21NO2

Formula Wt.

247.33

Chemical Name

1H-Pyrrole-2-carboxylic acid, 4-(3,7-dimethyl-2,6-octadienyl)-, (E)-

IUPAC Name

4-[(2E)-3,7-dimethylocta-2,6-dienyl]-1H-pyrrole-2-carboxylic acid

Synonym

EC 40

Solubility

Soluble in methanol, ethanol, or DMSO. Insoluble in water.

Appearance

Dark brown powder

Chekanov VS, Maternowski MA, Eisenstein R, et al. Angiogenesis in the latissimus dorsi muscle using different regimens of electrical stimulation and pharmaceutical support. ASAIO J. 2000 May-Jun;46(3):305-12. PMID: 10826742.

Kato S, Shindo K, Kawai H, et al. Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties. J Antibiot (Tokyo). 1993 Jun;46(6):892-9. PMID: 8344870.

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