Phyllolitorin
Phyllolitorin is a bombesin-related amphibian nonapeptide. Phyllolitorin induces contractions in urinary bladder smooth muscle and may play a role in lung branching morphogenesis. In mammals, phyllolitorin binds the gastrin-releasing peptide (GRP)-preferring bombesin receptor and the neuromedin B-preferring bombesin receptor. Phyllolitorin also elicits grooming and scratching behavior in mammalian animal models.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18954115
| Cas No. |
87734-77-8 |
|---|---|
| Purity |
≥95% |
| Formula |
C49H69N11O11S |
| Formula Wt. |
1020.24 |
| IUPAC Name |
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-5-oxopyrrolidine-2-carboxamide |
Lin JT, Coy DH, Mantey SA, et al. Comparison of the peptide structural requirements for high affinity interaction with bombesin receptors. Eur J Pharmacol. 1995 Dec 27;294(1):55-69. PMID: 8788416.
King KA, Torday JS, Sunday ME. Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4357-61. PMID: 7753811.
Masui A, Kato N, Itoshima T, et al. Scratching behavior induced by bombesin-related peptides. Comparison of bombesin, gastrin-releasing peptide and phyllolitorins. Eur J Pharmacol. 1993 Jul 20;238(2-3):297-301. PMID: 7691621.
Falconieri Erspamer G, Mazzanti G, Farruggia G, et al. Parallel bioassay of litorin and phyllolitorins on smooth muscle preparations. Peptides. 1984 Jul-Aug;5(4):765-8. PMID: 6494026.
