Phorbol-12-myristate-13-acetate
Phorbol-12-myristate-13-acetate (PMA) activates PKC and induces DNA damage. PMA exhibits pro-inflammatory, carcinogenic, and cytotoxic activities. This compound is often used in research models as a tumor promoter.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18953766
| Cas No. |
16561-29-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C36H56O8 |
| Formula Wt. |
616.84 |
| Chemical Name |
12-Tetradecanoyl phorbol-13-acetate |
| Synonym |
TPA; PMA; Tetradecanoylphorbol acetate; 4beta-Phorbol 12-myristate 13-acetate; Phorbol ester |
| Melting Point |
50-70°C |
| Solubility |
Soluble in DMSO, methanol, ethanol, ethyl acetate, or chloroform. Insoluble in water or aqueous buffer |
| Appearance |
Colorless Liquid |
Poachanukoon O, Koontongkaew S, Monthanapisut P, et al. Macrolides attenuate phorbol ester-induced tumor necrosis factor-α and mucin production from human airway epithelial cells. Pharmacology. 2014;93(1-2):92-9. PMID: 24556631.
Oskoueian E, Abdullah N, Ahmad S. Phorbol esters isolated from Jatropha meal induced apoptosis-mediated inhibition in proliferation of chang and Vero cell lines. Int J Mol Sci. 2012 Oct 24;13(11):13816-29. PMID: 23203036.
Colombo D, Tringali C, Franchini L, et al. Glycoglycerolipid analogues inhibit PKC translocation to the plasma membrane and downstream signaling pathways in PMA-treated fibroblasts and human glioblastoma cells, U87MG. Eur J Med Chem. 2011 May;46(5):1827-34. PMID: 21388717.
Birnboim HC. Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate. Can J Physiol Pharmacol. 1982 Nov;60(11):1359-66. PMID: 6295575.
