Phorbol-12,13-dibutyrate
Phorbol 12,3-dibutyrate (PBDu) activates PKC and PKD and induces apoptosis and differentiation in leukemia cells. PBDu is carcinogenic.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18953766
| Cas No. |
37558-16-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C30H46O8 |
| Formula Wt. |
504.61 |
| Synonym |
PBDu |
| Solubility |
Soluble in DMSO or ethanol. |
| Appearance |
Amorphous solid |
Aicart-Ramos C, Sánchez-Ruiloba L, Gómez-Parrizas M, et al. Protein kinase D activity controls endothelial nitric oxide synthesis. J Cell Sci. 2014 Aug 1;127(Pt 15):3360-72. PMID: 24928905.
Terui Y, Furukawa Y, Kikuchi J, et al. Apoptosis during HL-60 cell differentiation is closely related to a G0/G1 cell cycle arrest. J Cell Physiol. 1995 Jul;164(1):74-84. PMID: 7790399.
Rais S, Combadiere C, Hakim J, et al. Staurosporine up-regulates the expression of phorbol dibutyrate binding sites in human platelets. Biochem Pharmacol. 1994 May 18;47(10):1797-804. PMID: 8204096.
