Phenylbutazone
Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 activity; it is no longer used in humans, but was previously used to treat inflammatory diseases such as arthritis and gout. Phenylbutazone exhibits anti-inflammatory, analgesic, antipyretic, and antioxidative activities. In vivo, phenylbutazone decreases edema; in separate cellular models, it inhibits activity of myeloperoxidase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18953588
| Cas No. |
50-33-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C19H20N2O2 |
| Formula Wt. |
308.37 |
| Chemical Name |
4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione |
| IUPAC Name |
4-butyl-1,2-diphenylpyrazolidine-3,5-dione |
| Synonym |
Ambene; Artrizin; Butadion; Butoz; Equipalazone; Fenibutol; Intrabutazone; Phenyzene; Tevcodyne; Uzone |
| Melting Point |
105°C |
| Solubility |
Soluble in water. |
| Appearance |
White to off white powder |
Cusan C, Altinier G, Sosa S, et al. Anti-inflammatory and anti-oxidant activity of a new class of phenyl-pyrazolone derivatives. Curr Drug Discov Technol. 2006 Mar;3(1):67-73. PMID: 16712464.
Kettle AJ, Winterbourn CC. Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs. Biochem Pharmacol. 1991 May 15;41(10):1485-92. PMID: 1850278.
