Phellodendrine
Phellodendrine is a quaternary base alkaloid found in the bark of Phellodendron. Phellodendrine exhibits immunosuppressive and anti-inflammatory activities. Phellodendrine inhibits local semisyngenic and allogenic graft-versus-host (GVH) reactions and suppresses the induction of delayed-type hypersensitivity reactions without affecting the overall antibody response in animal models. Additionally, phellodendrine decreases urinary protein, plasma creatine, and plasma cholesterol levels in animal models of crescentic-type antiGBM nephritis, inhibiting crescent formation, adhesion, and fibrinoid necrosis in glomeruli; this compound also prevents nephritis-induced increases in immune cells and cytokines.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18953339
| Cas No. |
6873-13-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H24NO4 |
| Formula Wt. |
342.41 |
| IUPAC Name |
(7S,13aS)-3,10-dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,11-diol |
| Appearance |
White to off white powder |
Mori H, Fuchigami M, Inoue N, et al. Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responses. Planta Med. 1995 Feb;61(1):45-9. PMID: 7700991.
Hattori T, Furuta K, Hayashi K, et al. Studies on the antinephritic effects of plant components (6): antinephritic effects and mechanisms of phellodendrine (OB-5) on crescentic-type anti-GBM nephritis in rats (2). Jpn J Pharmacol. 1992 Nov;60(3):187-95. PMID: 1491511.
