Pepstatin
Pepstatin is a peptide originally found in Actinomyces; it inhibits aspartyl proteases such as pepsin and cathepsins D and E. Pepstatin may inhibit RANKL-induced osteoclast differentiation and phosphorylation of ERK.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18952907
| Cas No. |
26305-03-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C34H63N5O9 |
| Formula Wt. |
685.89 |
| Chemical Name |
L-Alaninamide, N-(3-methyl-1-oxobutyl)-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-((1S)-1-((1S)-2-carboxy-1-hydroxyethyl)-3-methylbutyl)- |
| IUPAC Name |
(3S,4S)-3-hydroxy-4-[[(2S)-2-[[(3S)-3-hydroxy-6-methyl-4-[[3-methyl-2-[[3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methylheptanoic acid |
| Synonym |
Pepstatin A |
| Melting Point |
228-229°C |
| Solubility |
Soluble in methanol, ethanol or DMSO. |
| Appearance |
White powder |
Marciniszyn J Jr, Hartsuck JA, Tang J. Mode of inhibition of acid proteases by pepstatin. J Biol Chem. 1976 Nov 25;251(22):7088-94. PMID: 993206.
Umezawa H, Aoyagi T, Morishima H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62. PMID: 4912600.
