Panaxadiol
Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) that exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. Panaxadiol inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential. This compound also increases superoxide dismutase activity and decreases malondialdehyde levels, improving cardiac function in animal models of burn injury. Additionally, panaxadiol improves efficacy of co-administered chemotherapeutics such as cyclophosphamide in animal models of melanoma and lung carcinoma.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18952604
| Cas No. |
19666-76-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C30H52O3 |
| Formula Wt. |
460.74 |
| IUPAC Name |
4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyloxan-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol |
| Solubility |
Soluble in DMSO |
| Appearance |
White Powder |
Wang Z, Zheng Q, Liu K, et al. Ginsenoside Rh(2) enhances antitumour activity and decreases genotoxic effect of cyclophosphamide. Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):411-5. PMID: 16623867.
Wang ZF, Xiao JS, Yan SZ, et al. Protective effects of panaxadiol saponins on cardiac functions in burned rats. Zhongguo Yao Li Xue Bao. 1995 Jul;16(4):345-8. PMID: 7668107.
Zhang WJ, Zhong GG, Jiang Y, et al. Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):173-6. PMID: 7516611.
