Oxytocin
Oxytocin is an endogenous peptide neurohormone that does not cross the blood-brain barrier. Oxytocin binds the oxytocin receptor (OXTR) and exhibits neuromodulatory, antinociceptive, antidepressant, anxiolytic, and other activities; it is involved with feelings of trust, memory, intimacy, and fidelity. Oxytocin also inhibits acid-sensing ion channels and may be used as a biomarker of bone mineral density.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18951947
| Cas No. |
50-56-6 |
|---|---|
| Purity |
≥95% |
| Formula |
C43H66N12O12S2 |
| Formula Wt. |
1007.2 |
| Chemical Name |
L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic (1-6)-disulfide |
| IUPAC Name |
1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-butan-2-yl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide |
| Synonym |
Ocytocin; Interocine-S; Perlacton; Pitocin; Syntocinon; Orasthin; Oxystin; Partocon. |
| Melting Point |
192-194°C |
| Solubility |
Soluble in water, 1-butanol or 2-butanol. |
| Appearance |
White to off-white powder |
Breuil V, Panaia-Ferrari P, Fontas E, et al. Oxytocin, a new determinant of bone mineral density in post-menopausal women: analysis of the OPUS cohort. J Clin Endocrinol Metab. 2014 Apr;99(4):E634-41. PMID: 24446658.
Yuen KW, Garner JP, Carson DS, et al. Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol. J Psychiatr Res. 2014 Apr;51:30-6. PMID: 24405552.
Qiu F, Qiu CY, Cai H, et al. Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin-1a receptor in primary sensory neurons. Br J Pharmacol. 2014 Feb 15. [Epub ahead of print]. PMID: 24641084.
Evans SL, Dal Monte O, Noble P, et al. Intranasal oxytocin effects on social cognition: A critique. Brain Res. 2013 Nov 14. [Epub ahead of print]. PMID: 24239931.
