Oxytetracycline
Oxytetracycline is a tetracycline antibiotic that exhibits broad spectrum antibacterial and anticancer efficacy; it is commonly used in veterinary medicine. Oxytetracycline inhibits t-RNA binding to ribosomes and inhibits proliferation of adenocarcinoma cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18951932
| Cas No. |
79-57-2 |
|---|---|
| Purity |
≥96% |
| Formula |
C22H24N2O9 |
| Formula Wt. |
460.43 |
| Chemical Name |
[4S-(4α,,4aα,5α,,5aα,,6β,12aα,)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydrothacenecarboxamide |
| IUPAC Name |
(4S,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide |
| Synonym |
Adamycin; Geotilin;Terramycin |
| Melting Point |
184-185°C |
| Solubility |
Insoluble in water (~0.24 mg/mL). Ethanol (15 mg/mL). |
| Appearance |
Yellow powder |
Strobel H, Lauseker M, Forbes AB. Targeted antibiotic treatment of lame sheep with footrot using either oxytetracycline or gamithromycin. Vet Rec. 2014 Jan 11;174(2):46. PMID: 24362004.
Shao J, Feng G. Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells. Chin J Cancer Res. 2013 Dec;25(6):662-70. PMID: 24385693.
Streltsov SA, Kukhanova MK, Gurskiĭ GV, et al. Oxytetracycline binding to E. coli ribosomes. Mol Biol (Mosk). 1975 Nov-Dec;9(6):910-21. PMID: 778591.
