Oxibendazole
Oxibendazole is a benzimidazole antifungal compound that also exhibits anti-parasitic and anti-helminthic activities. This compound inhibits microtubule polymerization. Oxibendazole is used in veterinary medicine, displaying efficacy against species of Coronocyclus, Cylicocyclus, Cyathostornum, Cylicostephanus, Strongylus, and Oxyuris.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18951678
| Cas No. |
20559-55-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H15N3O3 |
| Formula Wt. |
249.27 |
| Chemical Name |
(5-propoxy-1H-benzimidazol-2-yl) carbamic acid methyl ester |
| IUPAC Name |
methyl N-(6-propoxy-1H-benzimidazol-2-yl)carbamate |
| Synonym |
Equitac; SKF-30310; Anthelcide EQ |
| Melting Point |
230-230.5°C |
| Solubility |
Insoluble in water. Soluble in acetic acid and formic acid. |
| Appearance |
White or almost white crystalline powder |
Nielsen MK, Betancourt A, Lyons ET, et al. Characterization of the inflammatory response to anthelmintic treatment of ponies with cyathostominosis. Vet J. 2013 Nov;198(2):457-62. PMID: 24035469.
Traversa D, Iorio R, Otranto D, et al. Species-specific identification of equine cyathostomes resistant to fenbendazole and susceptible to oxibendazole and moxidectin by macroarray probing. Exp Parasitol. 2009 Jan;121(1):92-5. PMID: 18950625.
Kates KC, Colglazier ML, Enzie FD. Oxibendazole: critical anthelmintic trials in equids. Vet Rec. 1975 Dec 6;97(23):442-4. PMID: 1216434.
