Ornidazole
Ornidazole is a derivative of 5-nitroimidazole that exhibits antibacterial and anti-protozoan activity. Ornidazole is clinically used to treat dysentery and other symptoms of bacterial infection. Ornidazole is both cytotoxic and genotoxic and increases sister chromatid exchange and micronuclei formation in peripheral lymphocytes.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18951068
| Cas No. |
16773-42-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C7H10ClN3O3 |
| Formula Wt. |
219.63 |
| IUPAC Name |
1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol |
| Synonym |
Tiberal, Madelen |
| Melting Point |
85-90°C |
| Appearance |
White or Light Yellow Crystalline Powder |
Thulkar J, Kriplani A, Agarwal N. A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis. Indian J Pharmacol. 2012 Mar;44(2):243-5. PMID: 22529484.
Ikbal M, Yilmaz G, Dogan H, et al. The evaluation of genotoxic potential of ornidazole, nitroimidazole, in lymphocyte culture of patients with amebiasis. Drug Chem Toxicol. 2011 Apr;34(2):162-6. PMID: 21314465.
Raether W, Hänel H. Nitroheterocyclic drugs with broad spectrum activity. Parasitol Res. 2003 Jun;90 Supp 1:S19-39. PMID: 12811546.
