Oridonin
Oridonin is a diterpenoid found in Rabdosia rubescens. Oridonin has anti-inflammatory and antibacterial activity but is most widely known for its anticancer chemotherapeutic actions. This compound can bind HPS70 1A and can fit into the DNA double helix, provoking p53-mediated G2/M cell cycle arrest, apoptosis, and autophagy; these effects inhibit tumor growth in a wide variety of cell lines.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1895102
| Cas No. |
28957-04-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H28O6 |
| Formula Wt. |
364.43 |
| Chemical Name |
7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one |
| Synonym |
Isodonol, Rubescensin A (high purity) |
| Appearance |
White to off white powder |
Chen Z, Wang Z, Chen J, et al. Resonance light scattering technique as a new tool to determine the binding mode of anticancer drug oridonin to DNA. Eur J Med Chem. 2013 Aug;66:380-7. PMID: 23827178.
Dal Piaz F, Cotugno R, Lepore L, et al. Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells. J Proteomics. 2013 Apr 26;82:14-26. PMID: 23416714.
Yin B, Sheng H, Lin J, et al. The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. Int J Clin Exp Pathol. 2012;5(6):562-8. PMID: 22949939.
Li X, Li X, Wang J, et al. Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci. 2012;8(6):901-12. PMID: 22745580.
