Nisoldipine
Nisoldipine is an L-type Ca2+ channel blocker which with long-term treatment can prevent the development of hypertension and cardiac hypertrophy in young spontaneously hypertensive rats. It is a dihydropyridine analog that acts as an activator of the human pregnane X receptor, which in turn mediates activation of gene sets involved in the metabolism of xenobiotics.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18949096
| Cas No. |
63675-72-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H24N2O6 |
| Formula Wt. |
388.42 |
| IUPAC Name |
Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate |
Missan S, Zhabyeyev P, Dyachok O, et al. Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine. Br J Pharmacol. 2003 Nov; 140(5): 863-870. PMID: 14530219.
Stasch J, Kazda S, Hirth C, et al. Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive rats. Hypertension. 1987 Sep; 10(3): 303-307. PMID: 2957322.
Pan Y, Li L, Kim G, et al. Identification and Validation of Novel Human Pregnane X Receptor Activators among Prescribed Drugs via Ligand-Based Virtual Screening. Drug Metab Dispos. 2011 Feb; 39(2): 337-344. PMID: 21068194.
