Nimodipine
Nimodipine is an antagonist at L-type Ca2+ channels that exhibits antihypertensive, neuroprotective, neuromodulatory, cognition enhancing, and anti-inflammatory activities. In animal models of subarachnoid hemorrhage, nimodipine prevents cerebral ischemia and vasospasm. Nimodipine also inhibits methylmercury-induced behavioral neurotoxicity in vivo. In animal models of Alzheimer’s disease, nimodipine inhibits amyloid-β (Aβ)-stimulated release of IL-1β and resulting neurotoxicity. This compound also inhibits neurological symptoms of drug-induced withdrawal, suppressing anxiety, depression, and memory impairment.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18948957
| Cas No. |
66085-59-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C21H26N2O7 |
| Formula Wt. |
418.44 |
| Chemical Name |
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid 2-methoxyethyl 1-methyl- ethyl ester |
| IUPAC Name |
3-O-(2-methoxyethyl) 5-O-propan-2-yl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Synonym |
Periplum; Nimotop |
| Melting Point |
125°C |
| Solubility |
Soluble in methanol or DMSO. Insoluble in water. |
| Appearance |
Light yellow crystalline powder |
Bia A GY, Polak P, Michalak A, et al. Influence of calcium channel antagonists on nonsomatic signs of nicotine and d-amphetamine withdrawal in mice. Pharmacol Rep. 2014 Apr;66(2):212-22. PMID: 24911072.
Bailey JM, Hutsell BA, Newland MC. Dietary nimodipine delays the onset of methylmercury neurotoxicity in mice. Neurotoxicology. 2013 Jul;37:108-17. PMID: 23583802.
Sanz JM, Chiozzi P, Colaianna M, et al. Nimodipine inhibits IL-1β release stimulated by amyloid β from microglia. Br J Pharmacol. 2012 Dec;167(8):1702-11. PMID: 22831460.
Sharma N, Cho DH, Kim SY, et al. Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits. Neurol Res. 2012 Apr;34(3):291-6. PMID: 22450340.
Janjua N, Mayer SA. Cerebral vasospasm after subarachnoid hemorrhage. Curr Opin Crit Care. 2003 Apr;9(2):113-9. PMID: 12657973.
