Nimesulide
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2. Nimesulide exhibits anti-inflammatory, analgesic, antipyretic, and anticancer activities. Nimesulide is clinically used to treat arthritis, acute pain, and dysmenorrhea. In hypopharyngeal carcinoma cells, nimesulide decreases cell viability, increases apoptosis, downregulates expression of survivin, COX-2, and Bcl-2, and upregulates expression of caspase 3 and Bax. In vitro under inflammatory conditions, this compound decreases activity of PKC and release of substance P and prostaglandin E2 (PGE2).
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18948956
| Cas No. |
51803-78-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C13H12N2O5S |
| Formula Wt. |
308.31 |
| Chemical Name |
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide |
| IUPAC Name |
N-(4-nitro-2-phenoxyphenyl)methanesulfonamide |
| Synonym |
Aulin; Fansidol; Flogovital; Mesulid; Nide; Nidol; Nisulid |
| Melting Point |
143-144.5°C |
| Solubility |
Soluble in chloroform. |
| Appearance |
Yellowish Crystalline Powder |
Jia-Jun T, Su-Mei L, Liang Y, et al. Nimesulide inhibited the growth of hypopharyngeal carcinoma cells via suppressing Survivin expression. Head Neck Oncol. 2012 Mar 27;4:7. PMID: 22453101.
Vellani V, Franchi S, Prandini M, et al. Nimesulide inhibits protein kinase C epsilon and substance P in sensory neurons – comparison with paracetamol. J Pain Res. 2011;4:177-87. PMID: 21811393.
Suleyman H, Cadirci E, Albayrak A, et al. Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug. Curr Med Chem. 2008;15(3):278-83. PMID: 18333314.
