Nadifloxacin
Nadifloxacin is a fluoroquinolone antibiotic that exhibits antibacterial efficacy against both gram positive and gram negative bacteria; it inhibits DNA gyrase and is clinically used to treat acne vulgaris. Nadifloxacin inhibits Proponibacterium-stimulated PBMC production of IL-12, IFN-γ, and other cytokines. Nadifloxacin also decreases production of oxidative radicals by neutrophils.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18947877/
| Cas No. |
124858-35-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C19H21FN2O4 |
| Formula Wt. |
360.38 |
| Chemical Name |
(+-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid |
| Synonym |
Jinofloxacin; Acuatim |
| Melting Point |
245-247°C |
| Solubility |
Soluble in DMSO. |
| Appearance |
Pale yellow or yellow crystalline powder |
Takenaka Y, Hayashi N, Takeda M, et al. Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol. 2012 Apr;39(4):350-4. PMID: 21950544.
Kuwahara K, Kitazawa T, Kitagaki H, et al. Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes. J Dermatol Sci. 2005 Apr;38(1):47-55. PMID: 15795123.
Akamatsu H, Sasaki H, Kurokawa I, et al. Effect of nadifloxacin on neutrophil functions. J Int Med Res. 1995 Jan-Feb;23(1):19-26. PMID: 7774755.
