N-Acetyl-L-Cysteine
N-Acetyl-L-cysteine exhibits antioxidative, mucolytic, anti-inflammatory, antiviral, antipsychotic, and neuromodulatory activities. N-Acetyl-L-cysteine has clinically been used to treat acetaminophen overdose; it is occasionally commercially sold as a supplement. N-Acetyl-L-cysteine acts as a scavenger of ROS, decreasing oxidative stress in a variety of models. In vitro, this compound also inhibits TNF-α-induced increases in IL-6 release and NF-κB activation. N-Acetyl-L-cysteine also inhibits hepatitis B virus replication by suppressing viral assembly. Clinically, N-acetyl-L-cysteine displays potential benefit in the treatment of various mood disorders as it modulates reward and reinforcement signaling.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18946399
| Cas No. |
616-91-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C5H9NO3S |
| Formula Wt. |
163.20 |
| Chemical Name |
L-α-Acetamido-β-mercaptopropionic acid |
| IUPAC Name |
(2R)-2-acetamido-3-sulfanylpropanoic acid |
| Synonym |
Acetylcysteine; Brunac; Fabrol; Fluimucil; Fluprowit; Mucosil |
| Melting Point |
106-108°C |
| Solubility |
Soluble in water. |
| Appearance |
White Powder |
Lim JH, Lee YM, Park SR, et al. Anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells. Anticancer Res. 2014 Aug;34(8):4087-93. PMID: 25075033.
Grosicka-Maciąg E, Szumiło M, Czeczot H, et al. Modulation of antioxidant defense system by the dithiocarbamate fungicides Maneb and Zineb in Chinese hamster V79 cells and the role of N-acetyl-L-cysteine. Food Chem Toxicol. 2013 Oct;60:130-4. PMID: 23871785.
Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci. 2011 Mar;36(2):78-86. PMID: 21118657.
Weiss L, Hildt E, Hofschneider PH. Anti-hepatitis B virus activity of N-acetyl-L-cysteine (NAC): new aspects of a well-established drug. Antiviral Res. 1996 Aug;32(1):43-53. PMID: 8863995.
Shibanuma M, Kuroki T, Nose K. Inhibition by N-acetyl-L-cysteine of interleukin-6 mRNA induction and activation of NF kappa B by tumor necrosis factor alpha in a mouse fibroblastic cell line, Balb/3T3. FEBS Lett. 1994 Oct 10;353(1):62-6. PMID: 7926024.
