NMS-E628
NMS-E628 is an inhibitor of ALK anaplastic lymphoma kinase (ALK) and Ros1 and an antagonist at Trk receptors; it exhibits anticancer chemotherapeutic activity. Clinically, this compound suppresses tumor growth in non-small cell lung cancer (NSCLC) subjects with NTRK1 gene rearrangements.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18949427
| Cas No. |
1108743-60-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C31H34F2N6O2 |
| Formula Wt. |
560.64 |
| IUPAC Name |
N-[5-(3,5-Difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide |
| Synonym |
Entrectinib, RXDX-101 |
Amatu A, Somaschini A, Cerea G, et al. Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. Br J Cancer. 2015 Dec 3. [Epub ahead of print]. PMID: 26633560.
Farago AF, Le LP, Zheng Z, et al. Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2015 Nov 12. [Epub ahead of print]. PMID: 26565381.
Rolfo C, Ruiz R, Giovannetti E, et al. Entrectinib: a potent new TRK, ROS1, and ALK inhibitor. Expert Opin Investig Drugs. 2015 Nov;24(11):1493-500. PMID: 26457764.
