Mifepristone
Mifepristone is a synthetic steroid that exhibits abortifacient, contraceptive, neuroprotective, cognition enhancing, and antidepressant activities. Mifepristone inhibits the glucocorticoid receptor and progesterone receptor; it prevents ovulation and induces endometrial decidual degeneration. In vitro, mifepristone protects hippocampal cultures against oxidative stress and cell death induced by amyloid-β (Aβ), glutamate, and H2O2, suggesting potential benefit in the treatment of Alzheimer’s disease. Mifepristone also improves cognitive function, working memory, and spatial memory and improve symptoms of depression in clinical settings.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18945077
| Cas No. |
84371-65-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C29H35NO2 |
| Formula Wt. |
429.59 |
| Chemical Name |
(11β,17β)-11-[4-(Dimethylamino)phenyl]-17- hydroxy-17-(1-propynyl)estra-4,9-dien-3-one |
| IUPAC Name |
(8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one |
| Synonym |
RU-486; Mifegyne; Mifeprex |
| Melting Point |
150°C |
| Solubility |
Soluble in methanol, chloroform, or acetone. |
| Appearance |
Yellow Crystal Powder |
Fiala C, Gemzel-Danielsson K. Review of medical abortion using mifepristone in combination with a prostaglandin analogue. Contraception. 2006 Jul;74(1):66-86. PMID: 16781264.
Young AH, Gallagher P, Watson S, et al. Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology. 2004 Aug;29(8):1538-45. PMID: 15127079.
Behl C, Trapp T, Skutella T, et al. Protection against oxidative stress-induced neuronal cell death–a novel role for RU486. Eur J Neurosci. 1997 May;9(5):912-20. PMID: 9182944.
