Mastoparan
Mastoparan is an antimicrobial peptide (AMP) toxin originally found in wasp venom. Mastoparan increases GTPase activity and GTP binding, resulting in increases in Ca2+ influx. Mastoparan increases permeability of various cells; it induces degranulation and histamine release in mast cells. Additionally, this peptide inhibits production of TGF-β1 in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18941609
| Cas No. |
72093-21-1 |
|---|---|
| Purity |
≥95% |
| Formula |
C70H131N19O15 |
| Formula Wt. |
1478.92 |
| IUPAC Name |
(2S)-N-[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]butanediamide |
| Synonym |
Mast cell degranulating peptide (Vespula lewisii) |
| Solubility |
Soluble in CH3COOH (1mg/mL). |
| Appearance |
White to off white powder |
Brophy TM, Coller BS, Ahamed J. Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation. J Biol Chem. 2013 Apr 12;288(15):10628-39. PMID: 23463512.
Nakao S, Komagoe K, Inoue T, et al. Comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells. Biochim Biophys Acta. 2011 Jan;1808(1):490-7. PMID: 20955685.
Higashijima T, Uzu S, Nakajima T, et al. Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins). J Biol Chem. 1988 May 15;263(14):6491-4. PMID: 3129426.
