Lonidamine
Lonidamine inhibits glycolysis by inhibiting hexokinases; it exhibits anti-aging, anti-parasitic, and anti-fertility activities. Lonidamine increases lifespan in Caenorhabditis elegans, increasing stress resistance and promoting mitochondrial respiration by increasing levels of ROS. Lonidamine also displays antibiotic activity, causing death in Trypanosoma. In vivo, lonidamine increases testes weight and decreases sperm count and testosterone levels.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18940673
| Cas No. |
50264-69-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C15H10Cl2N2O2 |
| Formula Wt. |
321.16 |
| Chemical Name |
1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid |
| IUPAC Name |
1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid |
| Synonym |
Diclondazolic acid; DICA; AF-1890; Doridamina. |
| Melting Point |
207°C |
| Solubility |
Soluble in methanol or acetic acid. |
| Appearance |
White or off-white powder |
Schmeisser S, Zarse K, Ristow M. Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. Horm Metab Res. 2011 Sep;43(10):687-92. PMID: 21932172.
Chambers JW, Fowler ML, Morris MT, et al. The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. Mol Biochem Parasitol. 2008 Apr;158(2):202-7. PMID: 18262292.
Traina ME, Guarino M, Natoli A, et al. Lonidamine affects testicular steroid hormones in immature mice. Toxicol Appl Pharmacol. 2007 May 15;221(1):95-101. PMID: 17442358.
Ditonno P, Battaglia M, Selvaggio O, et al. Clinical Evidence Supporting the Role of Lonidamine for the Treatment of BPH. Rev Urol. 2005;7 Suppl 7:S27-33. PMID: 16986058.
