Lomustine
Lomustine is a nitrosourea alkylator that exhibits anticancer chemotherapeutic activity. Lomustine is clinically used to treat various forms of cancer and is one component of the “PCV” regimen.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18940657
| Cas No. |
13010-47-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C9H16ClN3O2 |
| Formula Wt. |
233.70 |
| Chemical Name |
N-(2-Chloroethyl)-N-cyclohexyl-N-nitrosourea |
| IUPAC Name |
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea |
| Synonym |
Belustine; Cecenu CeeNU; CiNU |
| Melting Point |
90°C |
| Solubility |
Soluble in ethanol or chloroform or acetone. |
| Appearance |
Yellowish Crystal |
Buccheri G, Ferrigno D, Rosso A. A phase II study of methotrexate, doxorubicin, cyclophosphamide, and lomustine chemotherapy and lonidamine in advanced non-small cell lung cancer. Cancer. 1993 Sep 1;72(5):1564-72. PMID: 8394198.
Kamiya S. Synthesis of antitumor nitrosourea derivatives and chemical studies of their mechanism of action. Eisei Shikenjo Hokoku. 1986;(104):1-19. PMID: 3471287.
