L-Tetrahydropalmatine
L-Tetrahydropalmatine is an alkaloid found in Corydalis and Stephania that exhibits analgesic, antidepressant, anxiolytic, cardioprotective, and neuromodulatory activities. L-Tetrahydropalmatine is the more active isomer of tetrahydropalmatine; it inhibits D1/2 receptors and suppresses reward and reinforcement signaling in animal models of substance abuse. L-Tetrahydropalmatine also increases time spent in open arms and decreases grooming behavior and immobility in various assays of anxiety and depression in vivo. Additionally, L-tetrahydropalmatine inhibits oxaliplatin-induced neuropathic pain in animal models. In animal models of myocardial ischemia/reperfusion, this compound decreases levels of NO and TNF-α, suppresses myeloperoxidase activity, and increases HIF-1α and VEGF levels.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18937034
| Cas No. |
483-14-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C21H25NO4 |
| Formula Wt. |
355.43 |
| Chemical Name |
5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H- dibenzo[a,g]quinolizine |
| IUPAC Name |
(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline |
| Synonym |
(-)-Tetrahydropalmatine; Gindarine; Rotundine; Caseanine; 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)-;13aa-Berbine, 2,3,9,10-tetramethoxy- (8CI); 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (S)-; Cyclanoline, O,O-dimethyl-N-demethyl- (6CI); Gindarine (7CI); (-)-2,3,9,10-Tetramethoxyberbine; (-)-Corydalis B; (-)-Rotundine; (-)-S-Tetrahydropalmatine; (-)-Tetrahydropalmatine; (S)-Tetrahydropalmatine; Caseanine; Hyndarine; N-Demethyl-O,O-dimethylcyclanoline; N-Demethyl-O,O-dimethylsteponine; Palmatine, tetrahydro-, (-)-; Rotundine; Rotundine (Stephania), (-)-; l-Tetrahydropalmatine |
| Melting Point |
147°C |
| Solubility |
DMSO |
| Appearance |
White yellowish crystalline |
Lee B, Sur B, Yeom M, et al. L-tetrahydropalmatine ameliorates development of anxiety and depression-related symptoms induced by single prolonged stress in rats. Biomol Ther (Seoul). 2014 May;22(3):213-22. PMID: 25009702.
Guo Z, Man Y, Wang X, et al. Levo-tetrahydropalmatine attenuates oxaliplatin-induced mechanical hyperalgesia in mice. Sci Rep. 2014 Jan 28;4:3905. PMID: 24469566.
Su HL, Zhu J, Chen YJ, et al. Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior. Physiol Behav. 2013 Jun 13;118:195-200. PMID: 23711566.
Han Y, Zhang W, Tang Y, et al. l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia-reperfusion injury in rats. PLoS One. 2012;7(6):e38627. PMID: 22715398.
