L-Citrulline
L-Citrulline is a by product of NO formation from metabolism of L-arginine that exhibits tocolytic and antioxidative activities. L-Citrulline was originally found in watermelon. In isolated rat uteri, L-citrulline decreases uterine contractile force through stimulation of the NO-cGMP relaxant pathway. L-Citrulline reverses NOS inhibitor-induced neurogenic vasodilation. In animal models, L-citrulline inhibits increases in iNOS and myeloperoxidase activity, inhibiting lipid peroxidation and attenuating ischemia/reperfusion-induced gastric damage. This compound may also inhibit neutrophil infiltration in animal models of ischemia/reperfusion.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18936875
| Cas No. |
372-75-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C6H13N3O3 |
| Formula Wt. |
175.19 |
| IUPAC Name |
(2S)-2-amino-5-(carbamoylamino)pentanoic acid |
| Melting Point |
214-216°C |
| Appearance |
White to off white powder |
Munglue P, Eumkep G, Wray S, et al. The effects of watermelon (Citrullus lanatus) extracts and L-citrulline on rat uterine contractility. Reprod Sci. 2013 Apr;20(4):437-48. PMID: 22991380.
Gou L, Zhang L, Yin C, et al. Protective effect of L-citrulline against acute gastric mucosal lesions induced by ischemia-reperfusion in rats. Can J Physiol Pharmacol. 2011 May;89(5):317-27. PMID: 21619416.
Lee TJ, Sarwinski S, Ishine T, et al. Inhibition of cerebral neurogenic vasodilation by L-glutamine and nitric oxide synthase inhibitors and its reversal by L-citrulline. J Pharmacol Exp Ther. 1996 Feb;276(2):353-8. PMID: 8632296.
