Kartogenin
Kartogenin stimulates chondrogenic differentiation of bone-derived mesenchymal stem cells (BMSCs) to improve repair of full-thickness cartilage defects in microfracture models. Kartogenin also induces formation of cartilage-like tissue and enhances wound healing in animal models. This compound may display pro-fibrotic activity. Kartogenin increases cartilage nodule formation, digit cartilaginous anlage elongation, synovial joint formation, and tendon maturation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18936456
| Cas No. |
4727-31-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H15NO3 |
| Formula Wt. |
317.34 |
| IUPAC Name |
2-(4-Biphenylylcarbamoyl)benzoic acid |
Liu C, Ma X, Li T, et al. Kartogenin, transforming growth factor-β1 and bone morphogenetic protein-7 coordinately enhance lubricin accumulation in bone-derived mesenchymal stem cells. Cell Biol Int. 2015 Apr 9. [Epub ahead of print]. PMID: 25857705.
Xu X, Shi D, Shen Y, et al. Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin. Arthritis Res Ther. 2015 Feb 2;17:20. PMID: 25641548.
Zhang J, Wang JH. Kartogenin induces cartilage-like tissue formation in tendon-bone junction. Bone Res. 2014;2. pii: 14008. PMID: 25419468.
Decker RS, Koyama E, Enomoto-Iwamoto M, et al. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin. Dev Biol. 2014 Nov 15;395(2):255-67. PMID: 25238962.
