K252c
K252c is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC and potentially PKA. K252c inhibits proliferation of human cytomegalovirus (CMV) and induces apoptosis in cancer cells, indicating some antiviral and anticancer chemotherapeutic activities.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18936182
| Cas No. |
85753-43-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H13N3O |
| Formula Wt. |
311.34 |
| IUPAC Name |
5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione |
| Solubility |
Soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol |
| Appearance |
White to off white powder |
Liu R, Zhu T, Li D, et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2. Arch Pharm Res. 2007 Mar;30(3):270-4. PMID: 17424930.
Zimmermann A, Wilts H, Lenhardt M, et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 Oct;48(1):49-60. PMID: 11080540.
Fabre S, Prudhomme M, Rapp M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem. 1993 Sep;1(3):193-6. PMID: 8081852.
