JW55
JW55 is an inhibitor of tankyrases (TNKS1/2) that stabilizes the β-catenin degradation complex, suppressing Wnt signaling. JW55 displays anti-obesity and potential anticancer activities. In animal models of high-fat diet and diabetes, JW55 decreases body weight and intestinal epithelial stem cell proliferation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18936141
| Cas No. |
664993-53-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C25H26N2O5 |
| Formula Wt. |
434.49 |
| IUPAC Name |
N-[4-({[4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl]methyl}carbamoyl)phenyl]-2-furamide |
Mao J, Hu X, Xiao Y, et al. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. PMID: 23884889.
Waaler J, Machon O, Tumova L, et al. A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753.
