Isoimperatorin
Isoimperatorin is a furocoumarin compound that exhibits anticancer chemotherapeutic, chemopreventive, anti-inflammatory, and antibacterial activities. In vitro, isoimperatorin induces cell cycle arrest at the G2/M phase and inhibits cell proliferation in melanoma cells; separately, it prevents activation of carcinogens such as PBTA-4 and MelQ. In vivo, isoimperatorin decreases tumor growth and tumor weight when combined with UVA irradiation. In cellular models, this compound decreases expression of ROS and vascular cellular adhesion molecule 1 (VCAM-1), increases expression of PPAR-γ, and inhibits NF-κB-induced phosphorylation of Akt, ERK, and PKC. In other cell lines, isoimperatorin inhibits activity of cyclooxygenase (COX-2), preventing production of leukotriene C4 and degranulation of bone marrow-derived mast cells. Additionally, isoimperatorin exhibits activity against both gram positive and gram negative bacteria.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931934
| Cas No. |
482-45-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H14O4 |
| Formula Wt. |
270.28 |
| IUPAC Name |
4-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one |
| Appearance |
Off-white crystals |
Kimura Y, Sumiyoshi M, Sakanaka M, et al. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells. Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25. PMID: 23802687.
Marumoto S, Oda Y, Miyazawa M. Antigenotoxic activity of naturally occurring furanocoumarins. Environ Mol Mutagen. 2011 Oct;52(8):646-57. PMID: 21786339
Moon L, Ha YM, Jang HJ, et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2011 Jan 27;133(2):336-44. PMID: 20937376.
Widelski J, Popova M, Graikou K, et al. Coumarins from Angelica lucida L.–antibacterial activities. Molecules. 2009 Jul 27;14(8):2729-34. PMID: 19701119.
Tang SY, Wang H, Zhang W, et al. Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action. Chem Res Toxicol. 2008 Dec;21(12):2414-23. PMID: 19548360.
Moon TC, Jin M, Son JK, et al. The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res. 2008 Feb;31(2):210-5. PMID: 18365692.
