Isoflurane
Isoflurane is an anesthetic most commonly used in veterinary medicine. Isoflurane exhibits cardiomodulatory, neuromodulatory, and pro-inflammatory activities. In diabetic rats, isofluorane decreases cardiac force and intracellular Ca2+ amplitude. Isoflurane also increases IL-6 and NF-κB levels in glioma cells and microglia. In other cellular models, isoflurane inhibits L-type voltage-gated Ca2+ channel currents at resting membrane potential. Additionally, isofluorane binds and modulates signaling by ATP synthase and NADH dehydrogenase. Isoflurane also inhibits delayed rectifier and A-type K+ channels and NMDA receptors, activates Ca2+ ATPase and ATP-sensitive K+ channels, and potentiates GABA-A and glycine (GlyR) receptors.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931884
| Cas No. |
26675-46-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C3H2ClF5O |
| Formula Wt. |
184.49 |
| IUPAC Name |
2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane |
| Appearance |
Clear and Colorless mobile heavy liquid |
Shen X, Bhatt N, Xu J, et al. Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from zucker diabetic Fatty rat. J Pharmacol Exp Ther. 2014 Apr;349(1):21-8. PMID: 24431470.
Fanchaouy M, Cubano L, Maldonado H, et al. PKC independent inhibition of voltage gated calcium channels by volatile anesthetics in freshly isolated vascular myocytes from the aorta. Cell Calcium. 2013 Oct;54(4):257-65. PMID: 23948226.
Zhang L, Zhang J, Yang L, et al. Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells. Br J Anaesth. 2013 Jun;110 Suppl 1:i82-91. PMID: 23604542.
