Indapamide
Indapamide is a thiazide-like diuretic that exhibits antihypertensive and anti-fibrotic activities. Indapamide is clinically used to treat hypertension and heart failure. Indapamide blocks the slow component of delayed rectifier currents (Kv7.1 and minK), potentially causing QT prolongation. In subjects with diabetes, indapamide decreases urine output and serum K+ and Cl- levels and increases renin activity. In spontaneously hypertensive rats, indapamide prevented increases in systolic blood pressure and the development of myocardial fibrosis without affecting NOS expression and NO levels.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931377
| Cas No. |
26807-65-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H16ClN3O3S |
| Formula Wt. |
365.84 |
| Chemical Name |
3-(Aminosulfonyl)-4-chloro-NN-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide |
| IUPAC Name |
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide |
| Synonym |
S-1520; Bajaten; Fludex; Indamol; Lozol; Natrilix; Veroxil |
| Melting Point |
160-162°C |
| Solubility |
Soluble in methanol, acetic acid and ethyl acetate. Slightly soluble in chloroform. |
| Appearance |
White or off-white crystal powder |
Janega P, Kojsová S, Jendeková L, et al. Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related. Physiol Res. 2007;56(6):825-8. PMID: 18197750.
Letsas KP, Alexanian IP, Pappas LK, et al. QT interval prolongation and torsade de pointes associated with indapamide. Int J Cardiol. 2006 Oct 10;112(3):373-4. PMID: 16260053.
Peng H, Zhou Z, Zhao W, et al. Study on the antidiuretic efficacy and mechanism of indapamide in central diabetes insipidus. Hunan Yi Ke Da Xue Xue Bao. 1999;24(3):259-62. PMID: 12016800.
