Hypothemycin
Hypothemycin is a polyketide found in Setophoma that exhibits anticancer, antifungal, and anti-parasitic activities. Hypothemycin is a resorcyclic acid lactone. This compound inhibits cell survival in melanoma and colon cancer cells. Hypothemycin also disrupts cell wall and endomembrane function in species of Pernophythora and suppresses growth of Trypanosoma in vitro and in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931330
| Cas No. |
76958-67-3 |
|---|---|
| Purity |
≥96% |
| Formula |
C19H22O8 |
| Formula Wt. |
378.37 |
| IUPAC Name |
(1aR,8S,10Z,13S,14S,15aR)-5,13,14-Trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione |
| Appearance |
White to off white powder |
El-Elimat T, Figueroa M, Raja HA, et al. Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris. European J Org Chem. 2015 Jan 1;2015(1):109-121. PMID: 25574154.
Xu L, Xue J, Wu P, et al. Antifungal activity of hypothemycin against Peronophythora litchii in vitro and in vivo. J Agric Food Chem. 2013 Oct 23;61(42):10091-5. PMID: 24106914.
Nishino M, Choy JW, Gushwa NN, et al. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 9;2:e00712. PMID: 23853713.
