Hexestrol
Hexestrol is a synthetic catechol that exhibits carcinogenic and estrogenic activities. Hexestrol inhibits tubulin assembly and induces mitotic arrest and aneuploidy in vitro. Hexestrol also forms DNA adducts, potentially initiating carcinogenesis.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18931005
| Cas No. |
84-16-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C18H22O2 |
| Formula Wt. |
270.37 |
| Chemical Name |
4,4-(1,2-Diethylethyl-1,2-ethanediyl)bisphenol |
| IUPAC Name |
4-[4-(4-hydroxyphenyl)hexan-3-yl]phenol |
| Synonym |
Dihydrodiethylstilbestrol; Synthovo; Cycloestrol; Hormoestrol; Syntrogene |
| Melting Point |
185-188°C |
| Solubility |
Soluble in ether, acetone, alcohol, and methanol. Slightly soluble in benzene and chloroform. |
| Appearance |
White or Almost White Crystalline Powder |
Cavalieri EL, Rogan EG. A unifying mechanism in the initiation of cancer and other diseases by catechol quinones. Ann N Y Acad Sci. 2004 Dec;1028:247-57. PMID: 15650250.
Chaudoreille MM, Peyrot V, Braguer D, et al. Qualitative study of the interaction mechanism of estrogenic drugs with tubulin. Biochem Pharmacol. 1991 Mar 1;41(5):685-93. PMID: 1847811.
Wheeler WJ, Cherry LM, Downs T, et al. Mitotic inhibition and aneuploidy induction by naturally occurring and synthetic estrogens in Chinese hamster cells in vitro. Mutat Res. 1986 Jul;171(1):31-41. PMID: 3724781.
