H89
H89 is an inhibitor of PKA that is used to study the effects of PKA signaling in research models. H89 may also inhibit Rho-associated protein kinase (ROCK), S6K1, MSK1, PKBa, and MAPKAP-K1b.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18930075
| Cas No. |
127243-85-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H22BrN3O2S |
| Formula Wt. |
446.36 |
| Chemical Name |
N-(2-[P-Bromocinnamylamino]-ethyl)-5-isoquinolinesulfonmide |
| IUPAC Name |
N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide;dihydrochloride |
| Melting Point |
141-143°C |
| Solubility |
Soluble in DMSO or ethanol:water (1:1). |
| Appearance |
White powder |
Choi S, Kim MY, Joo KY, et al. Modafinil inhibits K(Ca)3.1 currents and muscle contraction via a cAMP-dependent mechanism. Pharmacol Res. 2012 Jul;66(1):51-9. PMID: 22414869.
Rogers RC, Hermann GE. Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids. J Neurosci. 2012 Apr 11;32(15):5237-41. PMID: 22496569.
