Glimepiride
Glimepiride is a second generation sulfonylurea that exhibits anti-diabetic activity. Glimepiride inhibits ATP-dependent K+ channels in β cells, forcing cells to remain depolarized, increasing Ca2+ influx and insulin secretion. Glimepiride also exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-β (Aβ) in neurons in a PPARγ-dependent manner.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18927507
| Cas No. |
93479-97-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C24H34N4O5S |
| Formula Wt. |
490.62 |
| Chemical Name |
3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide |
| IUPAC Name |
4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide |
| Synonym |
HOE-490; Amarel |
| Melting Point |
212-215°C |
| Solubility |
Soluble in DMSO (25mg/mL). |
| Appearance |
White or almost white powder |
Liu F, Wang Y, Yan M, et al. Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons. Neurosci Lett. 2013 Dec 17;557 Pt B:90-4. PMID: 24184877.
Bashir MI, Pathan MF, Raza SA, et al. Role of oral hypoglycemic agents in the management of type 2 diabetes mellitus during Ramadan. Indian J Endocrinol Metab. 2012 Jul;16(4):503-7. PMID: 22837904.
Abdelmoneim AS, Hasenbank SE, Seubert JM, et al. Variations in tissue selectivity amongst insulin secretagogues: a systematic review. Diabetes Obes Metab. 2012 Feb;14(2):130-8. PMID: 21923736.
