Gefitinib
Gefitinib is an anticancer chemotherapeutic compound that inhibits mutant isoforms of EGFR. Across a variety of cancer cell lines, gefitinib increases poly(ADP)-ribose polymerase (PARP) cleavage and apoptosis, resulting in inhibition of cell growth. Gefitinib also induces expression of PPARγ in cellular models, likely through activation of transcription factor CCAT/enhancer binding protein β (CEBP-β). Gefitinib’s inhibition of EGFR also results in inhibition of heat shock protein 70 (HSP70), which can exacerbate pulmonary fibrosis. Additionally, gefitinib increases phosphorylation of p38 MAPK and JNK, inducing apoptosis in keratinocytes. This compound also promotes differentiation of acute myelogenous leukemia cells in vitro.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18926329
| Cas No. |
184475-35-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C22H24ClFN4O3 |
| Formula Wt. |
446.90 |
| Chemical Name |
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine |
| IUPAC Name |
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine |
| Melting Point |
212-214°C |
| Solubility |
DMSO (20 mg/ml), DMF (20 mg/ml) |
| Appearance |
White to off white powder |
Mansure JJ, Nassim R, Chevalier S, et al. A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer. PLoS One. 2013;8(2):e55997. doi: 10.1371/journal.pone.0055997. Erratum in: PLoS One. 2013; 8(5). PMID: 23409107.
Yoshida T, Yamada K, Azuma K, et al. Comparison of adverse events and efficacy between gefitinib and erlotinib in patients with non-small-cell lung cancer: a retrospective analysis. Med Oncol. 2013 Mar;30(1):349. PMID: 23263831.
Wan S, Wright DW, Coveney PV. Mechanism of drug efficacy within the EGF receptor revealed by microsecond molecular dynamics simulation. Mol Cancer Ther. 2012 Nov;11(11):2394-400. PMID: 22863610.
Namba T, Tanaka K, Hoshino T, et al. Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS One. 2011;6(11):e27296. PMID: 22096546.
Lu PH, Kuo TC, Chang KC, et al. Gefitinib-induced epidermal growth factor receptor-independent keratinocyte apoptosis is mediated by the JNK activation pathway. Br J Dermatol. 2011 Jan;164(1):38-46. PMID: 20846305.
Stegmaier K, Corsello SM, Ross KN, et al. Gefitinib induces myeloid differentiation of acute myeloid leukemia. Blood. 2005 Oct 15;106(8):2841-8. PMID: 15998836.
Tracy S, Mukohara T, Hansen M, et al. Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res. 2004 Oct 15;64(20):7241-4. PMID: 15492241.
