GW-5074
GW-5074 is an indole that functions as a highly selective Raf-1 (c-Raf) kinase inhibitor and is used to study Ras/Raf-1/ERK signaling. This compound inhibits desuccinylation activity of Sirt5 (a histone deacetylase), altering DNA repair and metabolism in vitro. GW-5074 is also neuroprotective against 6-OHDA toxicity, which is a commonly studied experimental model of Parkinson’s Disease.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929973
| Cas No. |
220904-83-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C15H8Br2INO2 |
| Formula Wt. |
520.94 |
| Chemical Name |
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo- |
| IUPAC Name |
(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one |
| Solubility |
DMSO 104 mg/mL |
Suenkel B, Fischer F, Steegborn C. Inhibition of the human deacylase Sirtuin 5 by the indole GW5074. Bioorg Med Chem Lett. 2013 Jan 1;23(1):143-6. PMID: 23195732.
Li J, Fan Y, Zhang YN, et al. The Raf-1 inhibitor GW5074 and the ERK1/2 pathway inhibitor U0126 ameliorate PC12 cells apoptosis induced by 6-hydroxydopamine. Pharmazie. 2012 Aug;67(8):718-24. PMID: 22957439.
