GSK-429286A
GSK-429286A is an inhibitor of ROCK1/2 that also exhibits some inhibition of RSK and p70S6K. GSK-429286A displays antihypertensive activity, decreasing mean arterial pressure in spontaneously hypertensive rats.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929638
| Cas No. |
864082-47-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C21H16F4N4O2 |
| Formula Wt. |
432.37 |
| IUPAC Name |
N-(6-fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide |
| Synonym |
GSK429286A |
| Appearance |
White to off white powder |
Nichols RJ, Dzamko N, Hutti JE, et al. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinsons disease. Biochem J. 2009 Oct 23;424(1):47-60. PMID: 19740074.
Goodman KB, Cui H, Dowdell SE, et al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem. 2007 Jan 11;50(1):6-9. PMID: 17201405.
