GSK-343
GSK-343 is an inhibitor of enhancer of zeste homolog 2 (EZH2) histone methyltransferase (HMT). GSK-343 exhibits anticancer activity, inhibiting cell invasion and cell growth in epithelial ovarian cancer cells.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18929533
| Cas No. |
1346704-33-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C31H39N7O2 |
| Formula Wt. |
541.69 |
| IUPAC Name |
N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide |
| Solubility |
Ethanol (2 mg/ml), DMSO (15 mg/ml), DMF (25 mg/ml) |
| Appearance |
Light Gray Powder |
Amatangelo MD, Garipov A, Li H, et al. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle. 2013 Jul 1;12(13):2113-9. PMID: 23759589.
